2026-05-10T12:10:23Z https://ijnpam.com/index.php/files/oai

oai:ojs2.ijnpam.com:article/1 2025-02-25T09:54:06Z files:ART

oai:ojs.ijnpam.com:article/3 2026-04-24T06:42:26Z files:ART

Plant-Based Remedies for Skin Disorders: Efficacy and Mechanisms of Action in Dermatological Treatments K. Purnachander Shweta Singh Nisha Rahul Baburao Ushir Ankit Kumar Ravi Kumar Skin disorders, Plant-based remedies, Dermatological treatments, Bioactive compounds, Anti-inflammatory, Antimicrobial, Antioxidant properties Skin disorders are among the most common health issues worldwide, affecting individuals of all ages and backgrounds. Traditional treatments for skin conditions often involve synthetic chemicals, which can cause side effects and long-term health risks. Plant-based remedies have gained attention in dermatology due to their natural origin, safety, and potential therapeutic benefits. This paper explores the efficacy of plant-based remedies in treating various skin disorders, including acne, eczema, psoriasis, and fungal infections. It examines the mechanisms of action of bioactive compounds found in plants, such as flavonoids, alkaloids, and terpenes, that contribute to their anti-inflammatory, antimicrobial, and antioxidant properties. The review also discusses the clinical evidence supporting the use of plant based remedies and highlights the challenges and opportunities in incorporating these natural alternatives into dermatological treatments. By evaluating the role of plant-based nanoparticles in drug delivery systems, the paper aims to present a comprehensive overview of how plant-derived compounds can offer effective solutions for improving skin health while minimizing side effects associated with conventional therapies. Sujata Publications 2025-03-20 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article application/pdf https://ijnpam.com/index.php/files/article/view/3 10.62896/ijnpam.v1.i1.01 International Journal of Natural Products and Alternative Medicine; IJNPAM: Volume 1 , Issue 1, January-June 2025; 1-8 3107-3646 eng https://ijnpam.com/index.php/files/article/view/3/3

oai:ojs.ijnpam.com:article/4 2026-04-24T06:43:26Z files:ART

Ethnopharmacological Insights into the Role of Medicinal Plants in Cardiovascular Health Richa Kashyap Jaffer Sadik Mohammed Ajeet Singh Ashok Kumar Sharma Prakash Srichand Sukhramani Ethnopharmacology, Medicinal Plants, Cardiovascular Diseases, Phytochemicals, Traditional Medicine, Cardioprotection Cardiovascular diseases (CVDs) remain the leading cause of morbidity and mortality worldwide, necessitating alternative and complementary therapeutic strategies. Ethnopharmacology, the study of medicinal plants used in traditional medicine, provides valuable insights into natural remedies for cardiovascular health. This review explores the role of medicinal plants in CVD prevention and management, emphasizing bioactive compounds with cardioprotective properties. Key phytochemicals such as flavonoids, alkaloids, polyphenols, and saponins demonstrate antihypertensive, lipid-lowering, antiplatelet, and antioxidant effects, contributing to improved cardiovascular function. Traditional medicine systems, including Ayurveda, Traditional Chinese Medicine (TCM), and Indigenous healing practices, have long utilized herbs like Terminalia arjuna, Panax ginseng, Allium sativum, and Crataegus spp. for their cardioprotective benefits. Recent pharmacological studies validate these traditional claims, highlighting their mechanisms of action, including nitric oxide modulation, inhibition of oxidative stress, and regulation of lipid metabolism. Despite promising findings, challenges such as standardization, bioavailability, and clinical validation remain critical. Further interdisciplinary research integrating ethnobotany, pharmacology, and clinical trials is essential to establish evidence-based phytotherapeutic interventions for cardiovascular health. Sujata Publications 2025-03-20 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article application/pdf https://ijnpam.com/index.php/files/article/view/4 10.62896/ijnpam.v1.i1.02 International Journal of Natural Products and Alternative Medicine; IJNPAM: Volume 1 , Issue 1, January-June 2025; 9-14 3107-3646 eng https://ijnpam.com/index.php/files/article/view/4/4

oai:ojs.ijnpam.com:article/5 2026-04-24T06:43:59Z files:ART

A Review of Plant-Based Natural Products for the Management of Diabetes: From Ethnobotany to Clinical Evidence Dritan Topi Chandan Kumar Dubey Shital Sharma Rohit Bushra Fasiha Suraj Mandal Diabetes mellitus, medicinal plants, ethnobotany, phytochemicals, antidiabetic activity, clinical evidence, insulin resistance. Diabetes mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia, resulting from insulin deficiency, insulin resistance, or both. Despite the availability of synthetic antidiabetic drugs, their long-term use is often associated with adverse effects, prompting interest in plant-based natural products as safer alternatives. This review explores the role of medicinal plants in diabetes management, tracing their use from ethnobotanical traditions to contemporary clinical applications. Various plant-derived bioactive compounds, including flavonoids, alkaloids, terpenoids, and polyphenols, have demonstrated antihyperglycemic, insulin-sensitizing, and pancreatic β-cell-protective effects through multiple mechanisms such as α-glucosidase inhibition, glucose uptake enhancement, and oxidative stress reduction. Key medicinal plants, such as Momordica charantia (bitter melon), Trigonella foenum-graecum (fenugreek), Cinnamomum verum (cinnamon), and Gymnema sylvestre, have shown promising results in preclinical and clinical studies. This review critically evaluates the pharmacological efficacy, mechanisms of action, and clinical evidence supporting the use of plant-based therapies for diabetes management. It also highlights challenges such as variability in bioactive compound concentrations, standardization, and regulatory concerns. The findings emphasize the potential of plant-based natural products as complementary or alternative therapies for diabetes while underscoring the need for further clinical validation and regulatory approval. Sujata Publications 2025-03-20 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article application/pdf https://ijnpam.com/index.php/files/article/view/5 10.62896/ijnpam.v1.i1.03 International Journal of Natural Products and Alternative Medicine; IJNPAM: Volume 1 , Issue 1, January-June 2025; 15-20 3107-3646 eng https://ijnpam.com/index.php/files/article/view/5/5

oai:ojs.ijnpam.com:article/6 2026-04-24T06:44:43Z files:ART

Recent Advances in the Isolation and Characterization of Antimicrobial Compounds Malarkodi Velraj Bhupinder Bhyan Rishikesh Mishram Rama Prasad Padhy Suraj Mandal s: Medicinal plants, antibiotic, viral infections, chromatography, mass spectrometry The increasing prevalence of antibiotic-resistant pathogens has heightened the need for new antimicrobial agents. Medicinal plants have long been a source of therapeutic compounds with promising antimicrobial properties. This paper reviews recent advances in the isolation and characterization of antimicrobial compounds from medicinal plants, highlighting novel methodologies and techniques in phytochemical analysis. Various plant species with significant antimicrobial activity are discussed, including those that show efficacy against resistant strains. The paper also explores the role of bioactive compounds such as alkaloids, flavonoids, terpenoids, and phenolic compounds in combating bacterial, fungal, and viral infections. Techniques such as chromatography, mass spectrometry, and nuclear magnetic resonance (NMR) spectroscopy have facilitated the identification and structural elucidation of these compounds. The potential for integrating these natural products into modern therapeutic strategies is also considered, alongside challenges such as standardization and toxicity evaluation. The findings underscore the importance of continued research in harnessing plant-derived antimicrobial agents as a viable solution to the growing antimicrobial resistance crisis. Sujata Publications 2025-03-20 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article application/pdf https://ijnpam.com/index.php/files/article/view/6 10.62896/ijnpam.v1.i1.04 International Journal of Natural Products and Alternative Medicine; IJNPAM: Volume 1 , Issue 1, January-June 2025; 21-27 3107-3646 eng https://ijnpam.com/index.php/files/article/view/6/6

oai:ojs.ijnpam.com:article/7 2026-04-24T06:45:10Z files:ART

The Role of Plant Metabolites in Enhancing Immunomodulatory Responses in Autoimmune Diseases Mohit Kotnala Prateek Porwal Subham Mandal Suraj Mandal Plant Metabolites, Immunomodulation, Autoimmune Diseases, Phytochemicals, Inflammatory Pathways, Natural Therapies Autoimmune diseases arise from an aberrant immune response against self-antigens, leading to chronic inflammation and tissue damage. Conventional therapies, including immunosuppressants and biologics, often present limitations such as side effects and high costs. Recent research has highlighted the potential of plant-derived metabolites in modulating immune responses, offering a natural and effective approach to managing autoimmune conditions. Bioactive compounds such as flavonoids, alkaloids, terpenoids, and polyphenols have demonstrated immunomodulatory properties by regulating pro-inflammatory cytokines, enhancing regulatory T cell function, and modulatingsignaling pathways such as NF-κB and JAK/STAT. Additionally, plant metabolites influence gut microbiota composition, which plays a crucial role in immune homeostasis. This review explores the therapeutic potential of plant metabolites in autoimmune diseases, discussing their mechanisms of action, sources, and clinical relevance. Further research is required to validate their efficacy and safety, paving the way for plantbased adjunct therapies in autoimmune disease management. Sujata Publications 2025-03-20 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article application/pdf https://ijnpam.com/index.php/files/article/view/7 10.62896/ijnpam.v1.i1.05 International Journal of Natural Products and Alternative Medicine; IJNPAM: Volume 1 , Issue 1, January-June 2025; 28-34 3107-3646 eng https://ijnpam.com/index.php/files/article/view/7/7

oai:ojs.ijnpam.com:article/8 2026-04-24T06:35:26Z files:ART

Investigation of the Antioxidant and Antimicrobial Properties of Elaeagnus latifolia Fruit Extract Sunil S. Karale Abhijeet S. Kulkarni Elaeagnus latifolia; Antioxidant Activity; DPPH; Free Radical; Antimicrobial Activity This study aims to provide scientific support for the high antioxidant and antimicrobial activity of the hydroalcoholic extract from the fruit of Elaeagnus latifolia. Elaeagnus latifolia, a plant belonging to the family Elaeagnaceae, is traditionally used for its medicinal properties, particularly as an antioxidant. The antioxidant activity of the extract was evaluated using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay. Preliminary phytochemical screening was performed to identify the presence of various bioactive compounds. The antimicrobial activity was assessed against a panel of pathogenic microorganisms, including Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis, and Candida albicans. The hydroalcoholic extract of Elaeagnus latifolia fruit was found to be a potent antioxidant, effectively scavenging free radicals. The phytochemical screening revealed the presence of alkaloids, sugars, carbohydrates, steroids, tannins, and flavonoids. The extract also demonstrated significant antimicrobial activity against the tested microorganisms. This work provides scientific validation for the traditional use of Elaeagnus latifolia. The observed antioxidant and antimicrobial activities are likely due to the presence of various phytochemicals, particularly flavonoids and tannins. The findings suggest that Elaeagnus latifolia may have potential applications in the treatment of diseases caused by free radicals and microbial infections. Sujata Publications 2025-12-15 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article application/pdf https://ijnpam.com/index.php/files/article/view/8 10.62896/ijnpam.v1.i2.01 International Journal of Natural Products and Alternative Medicine; IJNPAM: Volume 1 , Issue 2, July-December 2025; 1-6 3107-3646 eng https://ijnpam.com/index.php/files/article/view/8/8 Copyright (c) 2025 International Journal of Natural Products and Alternative Medicine

oai:ojs.ijnpam.com:article/9 2026-04-24T06:35:54Z files:ART

Phytochemical Profiling and Bioactivity Evaluation of Selected Medicinal Plants Rahul Shivaji Adnaik Phytochemical Profiling, Bioactivity, Medicinal Plants, Secondary Metabolites, Antioxidant Activity, Antimicrobial, Enzyme Inhibition, Traditional Medicine. This is an Open Access article that uses a funding model which does not charge readers or the Medicinal plants represent a vast, untapped reservoir of novel bioactive compounds with potential applications in pharmaceutical, food, and cosmetic industries. This manuscript details the comprehensive phytochemical profiling and subsequent bioactivity evaluation of a selection of medicinal plants historically used in traditional medicine systems. The study employs modern analytical techniques, including chromatography and spectroscopy, to characterize the diverse secondary metabolites present, focusing on key classes such as alkaloids, flavonoids, terpenoids, and polyphenols. Bioactivity evaluation encompasses assays designed to assess crucial pharmacological properties, including antioxidant capacity, antimicrobial efficacy, and enzyme inhibition (e.g., anti-inflammatory). Findings demonstrate a direct correlation between the abundance of specific phytochemicals (e.g., high phenolic content) and potent bioactivities. This research validates the traditional uses of these plants and provides a scientific foundation for the development of standardized, evidence-based phytomedicines, underscoring the vital link between chemical diversity and therapeutic potential. Sujata Publications 2025-12-15 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article application/pdf https://ijnpam.com/index.php/files/article/view/9 10.62896/ijnpam.v1.i2.02 International Journal of Natural Products and Alternative Medicine; IJNPAM: Volume 1 , Issue 2, July-December 2025; 7-12 3107-3646 eng https://ijnpam.com/index.php/files/article/view/9/9 Copyright (c) 2025 International Journal of Natural Products and Alternative Medicine

oai:ojs.ijnpam.com:article/10 2026-04-24T06:36:30Z files:ART

Exploring the use of Plant-Based Nanoparticles for Drug Delivery: Challenges and Opportunities Shweta Bhandari Plant-based nanoparticles [PBNs], Biocompatibility, Bioavailability, Targeted delivery, Therapeutic efficacy, Toxicity reduction The use of plant-based nanoparticles [PBNs] for drug delivery has gained significant attention in recent years due to their biocompatibility, ecofriendliness, and potential therapeutic efficacy. PBNs offer several advantages over conventional synthetic nanoparticles, such as reduced toxicity, lower immunogenicity, and better patient acceptance. This paper explores the opportunities and challenges associated with utilizing plantbased nanoparticles in drug delivery systems. Key opportunities include their ability to enhance the bioavailability of drugs, targeted delivery, and potential for use in personalized medicine. However, challenges such as scalability, regulatory hurdles, and variability in plant composition need to be addressed. The paper also discusses recent advancements in the development of plant-based nanocarriers, including their preparation methods, functionalization, and the types of drugs that can be delivered effectively. A comprehensive understanding of the mechanisms of action, safety profiles, and long-term effects of PBNs is crucial for their successful integration into clinical settings. Sujata Publications 2025-12-15 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article application/pdf https://ijnpam.com/index.php/files/article/view/10 10.62896/ijnpam.v1.i2.03 International Journal of Natural Products and Alternative Medicine; IJNPAM: Volume 1 , Issue 2, July-December 2025; 13-19 3107-3646 eng https://ijnpam.com/index.php/files/article/view/10/10 Copyright (c) 2025 International Journal of Natural Products and Alternative Medicine

oai:ojs.ijnpam.com:article/11 2026-04-24T06:37:03Z files:ART

Occupational and Environmental Carcinogens: Current Perspectives and Preventive Strategies Noor Glory Occupational carcinogens, environmental carcinogens, cancer prevention, workplace safety, exposure risk, public health, regulatory measures, preventive strategies, carcinogenic mechanisms, industrial practices Occupational and environmental carcinogens are significant contributors to the global burden of cancer, affecting workers and communities across various industries and regions. This paper explores the current perspectives on the identification, exposure, and impact of carcinogens found in workplaces and environmental settings. The research delves into the biological mechanisms by which these carcinogens lead to cancer, highlighting the role of genetic and environmental factors. Additionally, preventive strategies are examined, ranging from regulatory measures, risk assessments, and workplace interventions to public health initiatives aimed at reducing exposure. Emphasis is placed on the importance of early detection, education, and policy changes to mitigate the risks associated with occupational and environmental carcinogen exposure. The paper also discusses emerging trends and challenges, particularly the impact of new technologies and industrial practices, which may present both risks and opportunities for cancer prevention. Sujata Publications 2025-10-16 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article application/pdf https://ijnpam.com/index.php/files/article/view/11 10.62896/ijnpam.v1.i2.04 International Journal of Natural Products and Alternative Medicine; IJNPAM: Volume 1 , Issue 2, July-December 2025; 20-26 3107-3646 eng https://ijnpam.com/index.php/files/article/view/11/11 Copyright (c) 2025 International Journal of Natural Products and Alternative Medicine

oai:ojs.ijnpam.com:article/12 2026-04-24T06:41:39Z files:ART

Isolation, Characterization, and Therapeutic Potential of Bioactive Natural Compounds Prahllad Gain Bioactive Natural Compounds, Isolation, Structural Characterization, Therapeutic Potential, Nuclear Magnetic Resonance (NMR), Mass Spectrometry (MS), Drug Discovery, Bioactivity Screening. Bioactive natural compounds, primarily derived from plants, marine organisms, and microorganisms, are critical sources for drug discovery and development. This manuscript details the systematic process of isolation, structural characterization, and bioactivity assessment of novel compounds intended for therapeutic applications. The methodology encompasses initial crude extraction, targeted fractionation using advanced chromatographic techniques, and definitive structural elucidation employing sophisticated spectroscopic methods, particularly Nuclear Magnetic Resonance (NMR) spectroscopy and Mass Spectrometry (MS). The therapeutic potential is evaluated through in vitro assays assessing pharmacological actions such as cytotoxicity against cancer cell lines, antimicrobial efficacy, and enzyme inhibition relevant to chronic diseases. The analysis underscores that the structural diversity inherent in natural products offers unique scaffold diversity, which remains unparalleled by synthetic chemistry. This rigorous, evidence-based approach is vital for validating traditional medicinal knowledge and accelerating the pipeline for developing new, naturally derived pharmaceutical agents. Sujata Publications 2025-12-15 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article application/pdf https://ijnpam.com/index.php/files/article/view/12 10.62896/ijnpam.v1.i2.05 International Journal of Natural Products and Alternative Medicine; IJNPAM: Volume 1 , Issue 2, July-December 2025; 27-31 3107-3646 eng https://ijnpam.com/index.php/files/article/view/12/12 Copyright (c) 2025 International Journal of Natural Products and Alternative Medicine

oai:ojs.ijnpam.com:article/13 2026-04-03T07:03:42Z files:ART

SwALife Antioxidant Network Pharmacology Predictor: Designing the Future of Nutraceuticals with AI-Driven Antioxidant Modeling Pravin Badhe Antioxidant modeling; Network pharmacology; Artificial intelligence; Nutraceutical design; Systems biology; Computational pharmacology; Oxidative stress; Precision nutrition The increasing demand for evidence-based nutraceuticals has driven the integration of artificial intelligence and systems biology into antioxidant research. The SwALife Antioxidant Network Pharmacology Predictor represents an innovative AI-driven platform designed to model, predict, and optimize antioxidant activity through a network pharmacology framework. By integrating bioactive compound databases, molecular interaction networks, and predictive computational algorithms, SwALife enables comprehensive mapping of antioxidant–target–pathway relationships at a systems level. This approach facilitates the identification of multi-target mechanisms, synergistic interactions, and key signaling pathways involved in oxidative stress modulation. The platform supports rational nutraceutical design by providing in silico validation of antioxidant efficacy, safety, and functional relevance prior to experimental or clinical evaluation. Furthermore, SwALife enhances translational potential by bridging traditional nutraceutical knowledge with modern computational intelligence, enabling personalized and precision-oriented antioxidant interventions. Overall, the SwALife Antioxidant Network Pharmacology Predictor exemplifies a next-generation framework for nutraceutical innovation, accelerating discovery pipelines while improving scientific rigor, cost-efficiency, and predictive reliability in antioxidant modeling. Sujata Publications 2026-01-17 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article application/pdf https://ijnpam.com/index.php/files/article/view/13 10.62896/ijnpam.2.1.01 International Journal of Natural Products and Alternative Medicine; IJNPAM: Volume 2 , Issue 1, January-June 2026; 01-07 3107-3646 eng https://ijnpam.com/index.php/files/article/view/13/13 Copyright (c) 2026 International Journal of Natural Products and Alternative Medicine https://creativecommons.org/licenses/by-nc/4.0

oai:ojs.ijnpam.com:article/26 2026-04-03T07:03:42Z files:ART

White Paper: Allium Cepa Meristem Cell Analysis Pravin Badhe Md Khalid Aasia Alka Verma Allium cepa assay, Cytogenetic analysis, Meristem cell analysis, Genotoxicity testing, AI-assisted microscopy, Mitotic index, Image analysis Cytogenetic evaluation is fundamental to genotoxicity testing, environmental monitoring, and toxicological research, with the Allium cepa root meristem assay serving as a widely accepted model due to its sensitivity and reliability. However, conventional analysis relies on manual microscopy, making the process labor-intensive, timeconsuming, and susceptible to subjective interpretation. To address these limitations, this study presents an AI-assisted image analysis platform designed to automate Allium cepa meristem cell evaluation. The system integrates digital microscopy with computational image processing to identify mitotic phases, detect nuclear abnormalities, visualize chromosomal features, and automatically calculate cytogenetic indices such as the mitotic index and phase distribution. Pilot analyses indicate a marked reduction in analysis time, improved scoring accuracy, and enhanced reproducibility compared to traditional methods. In addition to research applications, the platform supports education by simplifying cytogenetic interpretation for students and early-career researchers. This AI-driven approach modernizes classical cytogenetic assays, offering a standardized, efficient, and scalable solution for genotoxicity testing and cytology-based studies. Sujata Publications 2026-02-14 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article application/pdf https://ijnpam.com/index.php/files/article/view/26 10.62896/ijnpam.2.1.02 International Journal of Natural Products and Alternative Medicine; IJNPAM: Volume 2 , Issue 1, January-June 2026; 8-12 3107-3646 eng https://ijnpam.com/index.php/files/article/view/26/20 Copyright (c) 2026 International Journal of Natural Products and Alternative Medicine

oai:ojs.ijnpam.com:article/28 2026-04-24T06:34:30Z files:ART

Research Synthesis of 2,4,5-Trisubstituted Imidazoles from Azido Chalcones and Nitriles B. Jhansi M. Thulasi A. Gayatri P. Ranjith P. Prabhavathi G. Srinivasa Rao α-Azido chalcones; 2,4,5-trisubstituted imidazoles; TMSOTf; Lewis acid catalysis; Thermal synthesis; Nitriles; Heterocyclic synthesis A simple and efficient synthetic route for the preparation of 2,4,5- trisubstituted imidazoles has been developed using α-azido chalcones and nitriles as key starting materials under Lewis acid-promoted thermal conditions. The present work explores the utility of α-azido chalcones as versatile intermediates for the synthesis of highly substituted imidazolederivatives. Various α-azido chalcones were reacted with aliphatic, vinyl, and aromatic nitriles in the presence of trimethylsilyl trifluoromethanesulfonate (TMSOTf) as a Lewis acid catalyst under solvent-free conditions at 80 °C. The reactions proceeded smoothly within 2 h to afford the corresponding 2,4,5-trisubstituted imidazoles in good yields (74–79%). The synthesized compounds were purified and characterized by melting point determination, thin-layer chromatography (TLC), infrared spectroscopy (IR), and proton nuclear magnetic resonance (^1H NMR) spectroscopy. Spectral data confirmed the formation of the desired imidazole derivatives, showing characteristic N–H, C=O, aromatic, and aliphatic/vinylic proton signals. The optimized method offers a rapid, efficient, and convenient approach for the synthesis of structurally diverse imidazole derivatives from α-azido chalcones. This protocol may serve as a useful strategy for the preparation of biologically relevant imidazole scaffolds for further medicinal and synthetic applications. Sujata Publications 2026-04-03 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article application/pdf https://ijnpam.com/index.php/files/article/view/28 10.62896/ijnpam.2.1.03 International Journal of Natural Products and Alternative Medicine; IJNPAM: Volume 2 , Issue 1, January-June 2026; 13-19 3107-3646 eng https://ijnpam.com/index.php/files/article/view/28/21 Copyright (c) 2026 International Journal of Natural Products and Alternative Medicine

oai:ojs.ijnpam.com:article/29 2026-04-24T06:34:30Z files:ART

Design, Synthesis and Characterization of Novel 2,4,5- Trisubstituted Oxazole Derivatives P. Mani K. Navya G. Kiran S. Reddy Beebi K. Umesh P. Prabhavathi G. Srinivasa Rao Oxazole derivatives; α-Azido chalcones; Potassium thiocyanate; Potassium persulfate; Cyclization; Heterocyclic synthesis; Oxazole-2-thiol A concise and efficient synthetic methodology for the preparation of substituted oxazole derivatives has been developed using readily accessible α-azido chalcones as key intermediates. The present work describes the synthesis of a series of 2,4,5-trisubstituted oxazole derivatives through a one-pot cyclization reaction involving substituted α-azido chalcones and potassium thiocyanate in the presence of potassium persulfate as an oxidant under mild reaction conditions. The reaction proceeds smoothly in dry acetonitrile under nitrogen atmosphere at 80 °C to afford the corresponding oxazole-2-thiol derivatives in good to excellent yields without the need for column chromatographic purification. Five representative compounds were synthesized and characterized by melting point determination, thin layer chromatography (TLC), infrared spectroscopy (IR), and ^1H NMR spectroscopy. The synthesized compounds showed yields ranging from 89– 95% and exhibited spectral characteristics consistent with the proposed structures. The present methodology offers significant advantages such as operational simplicity, shorter reaction time, high product yield, and broad substrate tolerance. The study demonstrates that α-azido chalcones are useful synthons for the construction of highly substituted oxazole frameworks, which are of considerable importance in medicinal chemistry due to their diverse biological activities. This work provides an efficient route for the synthesis of substituted oxazoles and may facilitate future exploration of their pharmacological potential. Sujata Publications 2026-04-03 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article application/pdf https://ijnpam.com/index.php/files/article/view/29 10.62896/ijnpam.2.1.04 International Journal of Natural Products and Alternative Medicine; IJNPAM: Volume 2 , Issue 1, January-June 2026; 20-27 3107-3646 eng https://ijnpam.com/index.php/files/article/view/29/22 Copyright (c) 2026 International Journal of Natural Products and Alternative Medicine

oai:ojs.ijnpam.com:article/31 2026-04-24T06:34:30Z files:ART

Preliminary Phytochemical Investigation, HPTLC Standardization and in-vitro Antidiabetic Activity of Stachytarpheta Urticifolia Leaf Ethanolic Extract Sk. Tamana Mehek D. Gandiswar P. Usha N. Santhosh P. Susmitha P. Prabhavathi G. Srinivasa Rao Stachytarpheta urticifolia; Anti-diabetic activity; α-Amylase inhibition; α-Glucosidase inhibition; Ethanol extract; Quercetin; HPTLC; Phenolic content Diabetes mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia resulting from defects in insulin secretion, insulin action, or both. Despite the availability of several synthetic anti-diabetic agents, their long-term use is often associated with adverse effects and limitations, necessitating the search formsafer and effective alternatives from natural sources. The present study was undertaken to evaluate the in vitro anti-diabetic potential of the ethanol extract of Stachytarpheta urticifolia leaves (EESU) by enzyme inhibition studies. Fresh leaves of Stachytarpheta urticifolia were collected, authenticated, dried, powdered, and successively extracted using petroleum ether, benzene, chloroform, ethanol, and water. Preliminary phytochemical screening was carried out using standard qualitative methods. Total phenolic content was estimated using the Folin–Ciocalteu reagent method, and HPTLC fingerprinting was performed for standardization of the ethanol extract using quercetin as the reference standard. The in vitro antidiabetic activity of EESU was evaluated by assessing α-amylase and α-glucosidase inhibitory activities at different concentrations, with acarbose used as the standard drug. Phytochemical screening revealed the presence of alkaloids, flavonoids, glycosides, tannins, polyphenols, saponins, triterpenoids, and amino acids in the ethanol extract. Among all extracts, the ethanol extract showed the highest percentage yield (26.63% w/w) and the highest total phenolic content (254.66 ±19.55). HPTLC analysis confirmed the presence of quercetin in the ethanol extract. EESU exhibited concentration-dependent inhibition of both α-amylase and αglucosidase enzymes, with IC₅₀ values of 269.88 µg/mL and 351.38 µg/mL, respectively, compared to acarbose with IC₅₀ values of 27.49 µg/mL and 25.07 µg/mL. The findings of the present study suggest that the ethanol extract of Stachytarpheta urticifolia leaves possesses promising in vitro anti-diabetic activity, which may be attributed to its rich phytochemical composition, particularly phenolic compounds and flavonoids such as quercetin. Further in vivo and mechanistic studies are warranted to validate its therapeutic potential as a natural anti-diabetic agent. Sujata Publications 2026-04-03 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article application/pdf https://ijnpam.com/index.php/files/article/view/31 10.62896/ijnpam.2.1.05 International Journal of Natural Products and Alternative Medicine; IJNPAM: Volume 2 , Issue 1, January-June 2026; 28-36 3107-3646 eng https://ijnpam.com/index.php/files/article/view/31/23 Copyright (c) 2026 International Journal of Natural Products and Alternative Medicine

oai:ojs.ijnpam.com:article/32 2026-04-24T06:34:30Z files:ART

Phytochemical Screening, HPTLC Standardization and in-vitro Antioxidant Activity of Ethanolic Extract of Stachytarpheta Urticifolia Leaves A. Kishore R. Anusha G. Sowjanya Selvam. K V. Nandini P. Prabhavathi G. Srinivasa Rao Stachytarpheta urticifolia; antioxidant activity; HPTLC; quercetin; total phenolic content; phytochemical screening; lipid peroxidation The ethanolic leaf extract of Stachytarpheta urticifolia demonstrated significant in vitro antioxidant activity, which may be attributed to its rich phenolic and flavonoid content, particularly quercetin. The findings support the traditional use of the plant and suggest that it may serve as a promising natural source of antioxidant phytoconstituents for further pharmacological investigation. Phytochemical screening revealed the presence of flavonoids, polyphenols, alkaloids, tannins, triterpenoids, saponins, carbohydrates, and amino acids in the ethanolic extract. Among all extracts, the ethanolic extract showed the highest percentage yield (26.63% w/w) and the highest total phenolic content (254.66 ± 19.55 mg QE/g extract). HPTLC fingerprinting of the ethanolic extract revealed 11 peaks, with a major peak at Rf 0.429 corresponding to quercetin, confirming its presence in the extract. The quercetin content was estimated to be approximately 0.214 mg/g of extract. In antioxidant studies, the ethanolic extract exhibited concentration-dependent activity in all assays. At 50 µg/mL, the extract showed 89.11 ± 3.15% inhibition in the superoxide radical scavenging assay and 89.26 ± 2.17% inhibition in the hydroxyl radical scavenging assay. In the lipid peroxidation assay, the extract showed 94.69 ± 3.12% inhibition at 250 µg/mL, which was higher than the standard. Sujata Publications 2026-04-04 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article application/pdf https://ijnpam.com/index.php/files/article/view/32 10.62896/ijnpam.2.1.06 International Journal of Natural Products and Alternative Medicine; IJNPAM: Volume 2 , Issue 1, January-June 2026; 37-42 3107-3646 eng https://ijnpam.com/index.php/files/article/view/32/24 Copyright (c) 2026 International Journal of Natural Products and Alternative Medicine

oai:ojs.ijnpam.com:article/34 2026-04-24T06:34:30Z files:ART

Review Article on Investigating the Antibacterial, Antifungal and Antiviral Efficacy of Andrographis Paniculata and Azadirachta Indica Extract Used in Traditional Indian Medicine Priya Kumari Ananya Anand Seema Yadav Shefali Singh Bhavya Kumari Anjali Sharma Ayushi Maloo Sarila Khan Andrographis paniculata, Azadirachta indica, Medicinal uses. This review highlights the need for additional analytical research to find novel drugs while attempting to summarize the plant's antibacterial and antifungal qualities. There is no denying the importance of natural ingredients in pharmaceuticals. From this perspective, Azadirachta indica is emerging as the cynosure of contemporary medicine. This plant has historically been widely used to treat a wide range of illnesses in both the plant and animal kingdoms. The pharmacological properties of neem plants have been linked to a variety of compounds. Aspergillus flavus, Alternaria solani, and Cladosporium were the three fungal species against which Azadirachta indica (neem) leaf extract was tested for antifungal activity. Ethanolic and methanolic extracts at different concentrations (25%, 50%, 75%, and 100%) were produced and tested against test organisms using disc diffusion. An antioxidant is a chemical that can stop the chain events that harm cells by eliminating free radical intermediates. It can also prevent other oxidation reactions by lowering the stress that causes many degenerative diseases. The versatile tropical herb Andrographis paniculata Nees is said to have numerous therapeutic benefits. This study aimed to assess the antioxidant activity of Andrographis paniculata Nees extracts in hexane, DCM, and methanol in vitro. The toxicity and antifungal properties of neem extract were compared using ketoconazole Sujata Publications 2026-04-23 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article application/pdf https://ijnpam.com/index.php/files/article/view/34 10.62896/ijnpam.2.1.07 International Journal of Natural Products and Alternative Medicine; IJNPAM: Volume 2 , Issue 1, January-June 2026; 43-48 3107-3646 eng https://ijnpam.com/index.php/files/article/view/34/25 Copyright (c) 2026 International Journal of Natural Products and Alternative Medicine

oai:ojs.ijnpam.com:article/37 2026-04-25T10:31:53Z files:ART

Formulation and Evaluation of Herbal Antiemetic Aromatherapy Roll-On Jadhav Yash A Bhoye Kailas P Damale Aviansh M Yeole Yash R Dr Deepak B. Somavanshi Emesis, Antiemetic, Aromatherapy, Essential oils, 5-HT₃ receptor, Peppermint, Ginger. This study focuses on the formulation and evaluation of a herbal antiemetic roll-on using essential oils derived from medicinal plants such as peppermint, ginger, lemon, and tulsi. Emesis (vomiting) is a complex physiological response triggered by various stimuli, including gastrointestinal irritation, motion sickness, pregnancy, and chemotherapy. Conventional antiemetic drugs, although effective, are often associated with adverse effects, creating a need for safer, natural alternatives. Aromatherapy, a holistic therapeutic approach utilizing essential oils, offers potential benefits in managing nausea and vomiting through olfactory and transdermal mechanisms. The formulated roll-on was prepared using selected essential oils blended with a carrier oil and evaluated for physicochemical properties and in-vitro antiemetic activity using a 5-HT₃ receptor binding assay. The results demonstrated a dosedependent inhibition of receptor binding, with a significant IC₅₀ value of 3.56 µg/mL, indicating promising antiemetic potential. The formulation exhibited comparable activity to standard drugs like ondansetron, suggesting its effectiveness as a natural alternative. Overall, the study highlights the therapeutic potential of herbal aromatherapy-based formulations in managing nausea and vomiting, with advantages such as improved patient compliance, reduced side effects, and ease of application. Further in-vivo and clinical studies are recommended to validate these findings. Sujata Publications 2026-04-25 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article application/pdf https://ijnpam.com/index.php/files/article/view/37 10.62896/ijnpam.2.1.08 International Journal of Natural Products and Alternative Medicine; IJNPAM: Volume 2 , Issue 1, January-June 2026; 49-53 3107-3646 eng https://ijnpam.com/index.php/files/article/view/37/26 Copyright (c) 2026 International Journal of Natural Products and Alternative Medicine